A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production

This journal club was held in Immunology, Asthma, and Allergy Research Institute

This journal club was held in the central auditorium of Immunology, Asthma, and Allergy Research Institute on Wednesday 7 May, 2016

Mohsen Badalzadeh, one of the researchers of Immunology, Asthma, and Allergy Research Institute and PhD student in molecular and cellular biology at Tehran University was the speaker of this journal club. He began his speech by reviewing asthma and its mechanism of action.
He explained  the results of a study conducted in University of California in which miRNA expression profiles of T cells in BAL fluid of patients with asthma, the regulatory role of miR-19a in producing TH2 cytokines, the role of miRNA in T CD4 + cell of mice, and their role in inflammation of the airway tract were investigated.
“In this study, the role of miR-19a on the expression of TH2 cytokines has been studied in many different ways. For example, the role of these mRNAs in T cells with no expression, normalized and over expression of miRNA in the production of cytokines such as IL-13, IL-4 and IL-5 was approved.” Badalzadeh said.
miR-19a acts by targeting Pten, SOCS1 and TNFAIP3 genes. The authors concluded that alternation in miRNA expression is crucial in the severity of disease. On the other hand, an miRNA can act in a different way. Strengthening the expression of these genes inhibiting miR-19a expression may reduce TH2 cytokines and ay be helpful in controlling asthma.
At the end of the session, her comprehensive presentation was appreciated and the issue was discussed

   2016/4/28 19:41    number of visits :  326

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