PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

This journal club was held in Immunology, Asthma, and Allergy Research Institute

This journal club was held in the central auditorium of Immunology, Asthma, and Allergy Research Institute on Wednesday 11 May, 2016

Mohammad Davoudzadeh Gholami, graduated student of immunology from Iran University of Medical Sciences was the speaker of this journal club. He started his lecture with an overview of cancer, hypoxic conditions in the tumor microenvironment, and inhibitors of immune system.
During this meeting, the results of a large joint research study between France, Italy and Luxembourg was explained. In that investigation, hypoxic condition was created for MDSC, macrophages, dendritic and tumor cells both in in-vitro and in-vivo condition. The results revealed that hypoxia leads to increased expression of PD-L1 on the surface of cells in the tumor microenvironment, but the effect of hypoxia on the expression of PD-L1 in these cells is different. They also demonstrated that hypoxia had no effect on the expression of PD-L2, CD80, CD86.
He pointed out that based on the results of this study, simultaneous usage of PD-L1 blocking antibodies and antibody neutralizing IL-10 may significantly reduce the inhibitory activity of MDSC cells in the tumor microenvironment. This can cause a considerable success in the treatment of cancer by immunotherapy.
At the end of the session, her comprehensive presentation was appreciated and the issue was discussed

   2016/5/12 19:51    number of visits :  321

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